Largaespada David A
University of Minnesota Cancer Center, 6-160 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 55455, USA.
Cancer Cell. 2003 Jul;4(1):3-4. doi: 10.1016/s1535-6108(03)00171-5.
In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal.
在本期《癌细胞》杂志中石田等人发表的论文里，作者报告了在小鼠中对一种名为SPA-1的Rap1特异性GTP酶激活蛋白（GAP）基因进行靶向失活的结果。在造血细胞中观察到Rap1过度激活，随着时间的推移，这导致了与人类骨髓发育异常和骨髓增殖性疾病典型症状相关的特征。作者还提供了其他数据，表明Rap1激活水平对于调节骨髓生成很重要，并且在适当的情况下可以传递致癌信号。
