Smoleński O, Tabarowski Z, Miszta H, Dabrowski Z
Department of Nephrology, Medical Academy, Cracow, Poland.
Int Urol Nephrol. 1992;24(6):673-8. doi: 10.1007/BF02551305.
The effect of haemodialysate and its 3 peptide fractions on lactate dehydrogenase activity in erythrocytes was studied in patients treated by repeated haemodialysis for end-stage renal disease and in healthy subjects. Erythrocytes from dialyzed patients showed significantly lower LDH activity than those from healthy subjects. After a 3-h incubation with haemodialysate (675 and 450 micrograms protein/ml), or its peptide fraction III (270 and 190 micrograms protein/ml), a significant inhibition of LDH activity was observed. On the other hand, neither haemodialysate nor its peptide fractions inhibited LDH activity in red blood cells from patients with end-stage renal disease treated by repeated haemodialysis.
在接受终末期肾病反复血液透析治疗的患者以及健康受试者中，研究了血液透析液及其3种肽组分对红细胞中乳酸脱氢酶活性的影响。透析患者的红细胞显示出的乳酸脱氢酶活性显著低于健康受试者。在用血液透析液（675和450微克蛋白质/毫升）或其肽组分III（270和190微克蛋白质/毫升）孵育3小时后，观察到乳酸脱氢酶活性受到显著抑制。另一方面，血液透析液及其肽组分均未抑制接受反复血液透析治疗的终末期肾病患者红细胞中的乳酸脱氢酶活性。
