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三种局部用抗真菌药单独及联合应用对癣菌的体外评价

In vitro evaluation of three topical antimycotics against ring-worm fungi singly and in combination.

作者信息

Rai M K, Upadhyay S K, Agrawal S C

机构信息

Department of Botany, Danielson College, Chhinwara.

出版信息

Hindustan Antibiot Bull. 1992 Aug-Nov;34(3-4):104-7.

PMID:1289296
Abstract

Three antimycotic drugs, viz., Miconazole nitrate, Econazole nitrate and ciclopirox olamine were tested singly and in combination of miconazole nitrate and Econazole nitrate, Miconazole nitrate and Ciclopirox olamine, and Econazole nitrate and Ciclopirox olamine to evaluate in vitro efficacy against Trichophyton mentagrophytes and Macrosporum nanum. The best efficacy was shown by Ciclopirox olamine (MIC 0.78 microgram/ml) and a combination of Miconazole nitrate and Econazole nitrate (MIC 0.78 microgram/ml).

摘要

测试了三种抗真菌药物，即硝酸咪康唑、硝酸益康唑和环吡酮胺，分别单独使用以及硝酸咪康唑与硝酸益康唑、硝酸咪康唑与环吡酮胺、硝酸益康唑与环吡酮胺联合使用，以评估其对须癣毛癣菌和短帚霉的体外抗菌效果。环吡酮胺（最低抑菌浓度为0.78微克/毫升）以及硝酸咪康唑与硝酸益康唑的组合（最低抑菌浓度为0.78微克/毫升）显示出最佳效果。

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