Martin Ludovic, Armingaud Pierre, Georgescu Voichita, Matre Frédéric, Legac Eric, Estève Eric
Service de Dermatologie, Hôpital Porte-Madeleine, BP 2439, CHR d'Orléans, 45032 Orléans Cedex, France.
J Am Acad Dermatol. 2003 Aug;49(2 Suppl Case Reports):S161-3. doi: 10.1067/mjd.2003.340.
We describe a female patient with an acute purpuric and bullous eruption mainly affecting the lower aspect of the legs. Skin biopsy specimens demonstrated microvascular occlusions with fibrin thrombi but no dermal inflammation. Intermediate hyperhomocysteinemia and transient antiphospholipid antibodies were evidenced as factors of thrombophilia. The responsibility of the latter in the onset of the cutaneous lesions is discussed.
我们描述了一名女性患者，其急性紫癜性和大疱性皮疹主要累及下肢。皮肤活检标本显示微血管闭塞并伴有纤维蛋白血栓，但无真皮炎症。中度高同型半胱氨酸血症和短暂性抗磷脂抗体被证实为血栓形成倾向的因素。本文讨论了后者在皮肤病变发生中的作用。
