Kurzchalia Teymuras V, Ward Samuel
Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, D-01307, Germany.
Nat Cell Biol. 2003 Aug;5(8):684-8. doi: 10.1038/ncb0803-684.
Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane structure. Instead, its most probable signalling functions are to control molting and induce a specialized non-feeding larval stage, although no cholesterol-derived signalling molecule has yet been identified for these or any other functions.
胆固醇是动物细胞膜的一种结构成分,会影响膜的流动性、通透性以及脂质微区的形成。它也是信号分子的前体,包括哺乳动物的甾体激素和昆虫的蜕皮激素。线虫秀丽隐杆线虫对胆固醇的需求量极少,以至于胆固醇在其膜结构中无法发挥主要作用。相反,其最可能的信号功能是控制蜕皮并诱导一个特殊的非摄食幼虫阶段,不过目前尚未鉴定出任何源自胆固醇的信号分子用于这些功能或其他功能。