Nagy Elisabeth, Marton Anna, Hajdú Edit
Department of Clinical Microbiology, Faculty of Medicine, University of Szeged, P.O. Box 427, H-6701 Szeged, Hungary.
Acta Microbiol Immunol Hung. 2003;50(2-3):119-24. doi: 10.1556/AMicr.50.2003.2-3.2.
Cefditoren is the active form of cefditoren pivoxil, a new, broad-spectrum oral cephalosporin with strong in vitro activity against penicillin-susceptible and resistant Streptococcus pneumoniae. In this study, the minimum inhibitory concentrations (MICs) of cefditoren were determined for a special selection of S. pneumoniae isolates known to be susceptible, moderately susceptible or fully resistant to penicillin; these isolates originated from the lower respiratory tract of adults with pneumonia or the upper respiratory tract of children with or without symptoms of infection. Some of this latter group of isolates exhibited extremely high MICs to penicillin (> or = 32 mg/l), whereas the MICs of cefditoren did not exceed 2 mg/l. The MIC50 and MIC90 of cefditoren proved to be 0.25 and 1.0 mg/l, respectively, with a range of MICs < or = 0.015-2.0 mg/l for all the tested S. pneumoniae isolates. Its good activity suggests that cefditoren is expected to be a potent drug in infections caused by penicillin-resistant and multidrug-resistant S. pneumoniae.
头孢妥仑是头孢妥仑匹酯的活性形式，头孢妥仑匹酯是一种新型广谱口服头孢菌素，对青霉素敏感和耐药的肺炎链球菌具有很强的体外活性。在本研究中，测定了头孢妥仑对一组经特殊挑选的肺炎链球菌分离株的最低抑菌浓度（MIC），这些分离株已知对青霉素敏感、中度敏感或完全耐药；这些分离株来自患有肺炎的成人的下呼吸道或有或无感染症状的儿童的上呼吸道。后一组分离株中的一些对青霉素表现出极高的MIC（≥32mg/L），而头孢妥仑的MIC不超过2mg/L。头孢妥仑的MIC50和MIC90分别为0.25和1.0mg/L，所有测试的肺炎链球菌分离株的MIC范围为≤0.015 - 2.0mg/L。其良好的活性表明，头孢妥仑有望成为治疗由耐青霉素和多重耐药肺炎链球菌引起的感染的有效药物。
