Zhu Xiaofeng, Chen Guihua, He Xiaoshun, Lu Minqiang, Wang Guodong, Cai Changjie, Yang Yang, Huang Jiefu
Transplantation Center, Affiliated First Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080.
Chin Med Sci J. 2002 Mar;17(1):44-6.
To investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China.
Ten patients with fulminant hepatitis B received orthotopic liver transplantation under veno-venous bypass. All patients had preoperatively serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro-hemorrhage. RUSULT: Seven of the 10 patients have survived for 3 approximately 18 months, but 3 died of multi-organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3 approximately 18 months without the signs of recurrence of hepatitis B.
Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.
