[维吾尔族宫颈鳞状细胞癌基因表达模式的研究]
[Investigation on the gene expression pattern in cervical squamous cell carcinoma of uygur].
作者信息
Liu Kai-jiang, Li Ting-fang, Zhao Feng, Wang Zhen-hua, Ge Chong-hua, Liu Qing
机构信息
Department of Gynecologic Oncology, Affiliated Cancer Hospital of Xinjiang Medical University, Wulumuqi 830011, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2003 Jun;38(6):325-7.
OBJECTIVE
To investigate the differentially expressed gene in cervical squamous cell carcinoma of uygur and normal cervical tissue using gene chip.
METHOD
Gene chips containing 2,048 human genes were used to investigate the gene expression pattern of 3 samples of cervical cancer.
RESULT
By applying this gene chip we identified 64 differentially expressed genes in all 3 clinical cervical cancer samples, and we further identified 53 upregulated and 11 downregulated genes for functional analysis.
CONCLUSION
The analysis of gene expression pattern of tumor based on gene chip can realize high-throughput screening of the genes associated with the cervical cancer.
目的
利用基因芯片研究维吾尔族宫颈鳞状细胞癌组织与正常宫颈组织中差异表达的基因。
方法
采用含有2048个人类基因的基因芯片检测3例宫颈癌组织的基因表达谱。
结果
应用该基因芯片，在所有3例临床宫颈癌样本中鉴定出64个差异表达基因，进一步鉴定出53个上调基因和11个下调基因用于功能分析。
结论
基于基因芯片的肿瘤基因表达谱分析可实现与宫颈癌相关基因的高通量筛选。
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