Diaz Bruno L, Arm Jonathan P
Division of Cell Biology, National Cancer Institute-INCA, R André Cavalcanti 37, Centro, Rio de Janeiro 20231-050, Brazil.
Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep;69(2-3):87-97. doi: 10.1016/s0952-3278(03)00069-3.
Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA(2) enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.
在表征参与生成类二十烷酸（从花生四烯酸衍生而来的脂质介质，如前列腺素和白三烯）的各个酶及其相对贡献方面已取得了相当大的进展。然而，在生物过程中，个别磷脂酶A2（PLA2）酶在为下游酶提供花生四烯酸以生成类二十烷酸方面的作用尚未完全阐明。在本综述中，我们将概述PLA2酶家族的分类、其假定的作用机制，以及它们在类二十烷酸生成和炎症中的作用。
