O'Neal R B, Sauk J J, Somerman M J
University of Michigan Dental School, Ann Arbor 48109.
J Oral Implantol. 1992;18(3):243-55.
The recognition that synthetic devices can provide functional replacements for failed teeth, or for previously edentulous areas, has resulted in increased emphasis being placed on understanding of the interactions between synthetic materials and host tissues in order for the success of these devices to be optimized. A key to achievement of an optimal biological interface between the implant and the surrounding tissue is through an understanding of host response to materials. This article reviews the biological requirements for implant-tissue integration, with specific focus on the role of adhesion molecules and cytokines (growth factors) in this process. Adhesion molecule/cytokine interactions are discussed, and in particular the possible role for osteopontin, an adhesion molecule as well as a cytokine, is considered in wound healing. Finally, the causes of peri-implantitis are discussed, and methods of decontamination are presented. The decontamination methods focus on enhancement of cell adhesion and integration to the altered implant surface.
认识到合成装置可以为功能失效的牙齿或先前无牙的区域提供功能替代物，这使得人们越来越重视理解合成材料与宿主组织之间的相互作用，以便优化这些装置的成功率。实现植入物与周围组织之间最佳生物界面的关键在于了解宿主对材料的反应。本文回顾了植入物与组织整合的生物学要求，特别关注粘附分子和细胞因子（生长因子）在此过程中的作用。讨论了粘附分子/细胞因子的相互作用，尤其考虑了骨桥蛋白（一种既是粘附分子又是细胞因子）在伤口愈合中的可能作用。最后，讨论了种植体周围炎的病因，并介绍了去污方法。去污方法侧重于增强细胞对改变后的植入物表面的粘附和整合。
