Saugstad Ola D, Ramji Siddarth, Irani Simin F, El-Meneza Safaa, Hernandez Emil A, Vento Maximo, Talvik Tiina, Solberg Rønnaug, Rootwelt Terje, Aalen Odd O
Department of Pediatric Research, Rikshospitalet, University of Oslo, Oslo, Norway.
Pediatrics. 2003 Aug;112(2):296-300. doi: 10.1542/peds.112.2.296.
To follow-up children who had been resuscitated at birth with either 21% or 100% oxygen (O2).
A multicenter study with 10 participating centers recruited 609 infants to the Resair 2 study where resuscitation was performed with either 21% or 100% O2. A follow-up between ages 18 and 24 months was performed. However, during follow-up registration, it was found that 18 infants had been enrolled twice in the original Resair 2 study with different registration numbers, leaving 591 enrolled in the Resair 2 study and 410 enrolled in the 7 centers participating in the follow-up. Of these 410 infants, 79 died (76 in the neonatal and 3 in the postneonatal period). Furthermore, for 8 infants informed consent was not obtained, leaving 323 eligible for follow-up. Of these, 213 infants (66%) were followed-up: 91 (62%) had been resuscitated with 21% O2, and 122 (69%) with 100% O2. At a median age of 22 and 20 months (not significant) in the 21% and 100% groups, respectively, a simple questionnaire was filled out and neurologic assessment was performed in addition to measuring anthropometric data.
There were no significant differences in weight, height, or head circumference between the 2 groups. Cerebral palsy developed in 10% and 7%, respectively, in the 2 groups (not significant). In total, 11 cases (12%) in the 21% versus 11 cases (9%) in the 100% O(2) group (odds ratio: 1.39, 95% confidence interval: 0.57-3.36) developed cerebral palsy and/or mental or other delay. Furthermore, it was concluded that 14 (15%) in the 21% group and 12 (10%) in the 100% group were not normal (odds ratio: 1.67, 95% confidence interval: 0.73-3.80).
There were no significant differences in somatic growth or neurologic handicap at an age of 18 to 24 months in infants resuscitated with either 21% or 100% O2 at birth. Based on these data, resuscitation with ambient air seems to be safe, at least in most cases. More studies are needed to settle this issue.
对出生时接受21%或100%氧气复苏的儿童进行随访。
一项多中心研究，10个参与中心招募了609名婴儿参与Resair 2研究，该研究中复苏采用21%或100%的氧气。在18至24个月龄时进行随访。然而，在随访登记过程中，发现有18名婴儿在最初的Resair 2研究中被重复登记，登记编号不同，因此Resair 2研究中实际登记的有591名婴儿，7个参与随访的中心登记了410名婴儿。在这410名婴儿中，79名死亡（76名在新生儿期，3名在新生儿后期）。此外，有8名婴儿未获得知情同意，因此有323名符合随访条件。其中，213名婴儿（66%）接受了随访：91名（62%）接受了21%氧气的复苏，122名（69%）接受了100%氧气的复苏。在21%氧气组和100%氧气组中，分别在22个月和20个月的中位年龄（无显著差异）时，填写了一份简单问卷，并进行了神经学评估，同时测量了人体测量数据。
两组之间在体重、身高或头围方面无显著差异。两组中分别有10%和7%的儿童患脑性瘫痪（无显著差异）。总体而言，21%氧气组有11例（12%），100%氧气组有11例（9%）患脑性瘫痪和/或智力或其他发育迟缓（比值比：1.39，95%置信区间：0.57 - 3.36）。此外，得出结论：21%氧气组中有14名（15%）、100%氧气组中有12名（10%）发育不正常（比值比：1.67，95%置信区间：0.73 - 3.80）。
出生时接受21%或100%氧气复苏的婴儿在18至24个月龄时，在身体生长或神经功能障碍方面无显著差异。基于这些数据，至少在大多数情况下，用空气进行复苏似乎是安全的。需要更多研究来解决这个问题。
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