Kaneda Yasuhiro
Psychopharmacology Division, Psychiatric Hospital at Vanderbilt, 1601 23rd Avenue South, Suite 306, Nashville, TN 37212, USA.
Clin Neuropharmacol. 2003 Jul-Aug;26(4):182-4. doi: 10.1097/00002826-200307000-00006.
In this cross-sectional study, the author tested the hypothesis that prolactin elevation with antipsychotic medications was associated with low subjective quality-of-life scores in patients with schizophrenia. The subjects were 42 male inpatients meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for schizophrenia on typical antipsychotics. No correlations were found between prolactin or testosterone and the 3 subscales in the Japanese version of the Schizophrenia Quality of Life Scale. Multiple regression analyses showed total variance in the ratings of 3 subscales in the Japanese version of the Schizophrenia Quality of Life Scale as follows: Brief Psychiatric Rating Scale (BPRS) anxiety/depression factor, dosage of antipsychotics and BPRS hostile/suspiciousness factor in the psychosocial subscale (adjusted R2 = 0.394), BPRS anxiety/depression factor and dose of antipsychotics in the motivation/energy subscale (adjusted R2 = 0.475), and dose of antipsychotics and BPRS anergia factor in the symptoms/side effects subscale (adjusted R2 = 0.206). The results did not support the hypothesis.
在这项横断面研究中，作者检验了以下假设：抗精神病药物导致的催乳素升高与精神分裂症患者较低的主观生活质量评分相关。研究对象为42名符合《精神疾病诊断与统计手册》第4版精神分裂症标准且正在服用典型抗精神病药物的男性住院患者。在日本版精神分裂症生活质量量表中，未发现催乳素或睾酮与3个分量表之间存在相关性。多元回归分析显示，日本版精神分裂症生活质量量表3个分量表评分的总方差如下：社会心理分量表中的简明精神病评定量表（BPRS）焦虑/抑郁因子、抗精神病药物剂量以及BPRS敌对/猜疑因子（调整后R2 = 0.394）；动机/活力分量表中的BPRS焦虑/抑郁因子和抗精神病药物剂量（调整后R2 = 0.475）；症状/副作用分量表中的抗精神病药物剂量和BPRS无活力因子（调整后R2 = 0.206）。研究结果不支持该假设。
