Wiest Michael C, Nicolelis Miguel A L
Department of Neurobiology, Box 3209, Duke Medical Center, Durham, North Carolina 27710, USA.
Nat Neurosci. 2003 Sep;6(9):913-4. doi: 10.1038/nn1107.
Prominent 7-12 Hz oscillations in the primary somatosensory cortex (S1) of awake but immobile rats might represent a seizure-like state in which neuronal burst firing renders animals unresponsive to incoming tactile stimuli; others have proposed that these oscillations are analogous to human mu rhythm. To test whether rats can respond to tactile stimuli during 7-12 Hz oscillatory activity, we trained head-immobilized awake animals to indicate whether they could detect the occurrence of transient whisker deflections while we recorded local field potentials (LFPs) from microelectrode arrays implanted bilaterally in the S1 whisker representation area. They responded rapidly and reliably, suggesting that this brain rhythm represents normal physiological activity that does not preclude perception.
清醒但不动的大鼠初级体感皮层（S1）中显著的7-12赫兹振荡可能代表一种癫痫样状态，在此状态下神经元爆发式放电使动物对传入的触觉刺激无反应；其他人则提出这些振荡类似于人类的μ节律。为了测试大鼠在7-12赫兹振荡活动期间是否能对触觉刺激做出反应，我们训练头部固定的清醒动物，在我们从双侧植入S1胡须表征区域的微电极阵列记录局部场电位（LFP）时，指示它们是否能检测到短暂的胡须偏转的发生。它们反应迅速且可靠，这表明这种脑节律代表正常的生理活动，并不妨碍感知。
