Wu Zhenghua, Huang Xin, Kang Feiwu
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Jun;21(3):194-6.
The purpose of this study was to discuss the principle in neck treatment of cN0 patients with squamous cell carcinoma of buccal mucosa.
101 patients of squamous cell carcinoma of buccal mucosa at the stage of cN0, who had hospitalized in West China College of Stomatology, Sichuan University from 1980 to 2000, were investigated retrospectively. All the patients received a comprehensive therapy consisting of surgical procedures combined with chemotherapy and radiotherapy. The combining radical therapy of buccal, mandible and neck was the main surgical method. Lymph nodes were cleared after operation and examined by pathological method. The patients had been followed up for more than 3 years.
17 patients had lymph nodes metastasis, the occult metastasis (OM) rate was 16.83%. It increased in the high stage of original lesion, the OM rate of T3 and T4 was 18.18% and 52.00%, respectively. The metastasized lymph nodes were mainly located in submandible and superior deep cervix lymph nodes, their respective metastasis rate was 41.18% and 29.41%.
The rate of occult metastasis of squamous cell carcinoma of buccal mucosa is high, and then we should adopt actively selective neck dissection for the cN0 patients of squamous cell carcinoma of buccal mucosa.
本研究旨在探讨颊黏膜鳞状细胞癌cN0患者颈部治疗的原则。
回顾性调查1980年至2000年在四川大学华西口腔医学院住院的101例颊黏膜鳞状细胞癌cN0期患者。所有患者均接受了手术联合化疗和放疗的综合治疗。颊部、下颌骨和颈部联合根治术是主要手术方式。术后清扫淋巴结并进行病理检查。患者随访超过3年。
17例患者发生淋巴结转移，隐匿性转移（OM）率为16.83%。在原发灶高分期中其发生率增加，T3和T4的OM率分别为18.18%和52.00%。转移淋巴结主要位于下颌下和颈深上淋巴结，其转移率分别为41.18%和29.41%。
颊黏膜鳞状细胞癌隐匿性转移率较高，对于颊黏膜鳞状细胞癌cN0患者应积极采取选择性颈清扫术。
