Zarebska Alicja, Łańcut MirosŁaw, Sekita-Krzak Joanna, Visconti Józef, Czerny Krystyna
Department of Histology and Embryology, Laboratory for Experimental Cytology, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2002;57(1):452-8.
The experiment was carried out on Wistar rat males weighting about 200 g. Animals from experimental group I received 20% ethanol for drinking (ad libitum), animals from experimental group II--cephalexin in the dose of 42 mg/24 h, animals from experimental group III--cephalexin and ethanol in the mentioned doses. After 10 days the animals were decapitated and pancreases were collected for ultrastructural examinations in electron microscope. The performed experiments showed that 10-day administration of ethanol causes mainly the decrease of amount of ribosomes and zymogen granules in pancreatic exocrine cells, whereas cephalexin causes increase of amount of these organelles. Administration of both ethanol and cephalexin causes reversible degenerative changes including distinct decreasing of the number of ribosomes, swelling of many mitochondria and the presence of myelinic structures inside cells.
实验在体重约200克的雄性Wistar大鼠身上进行。实验组I的动物饮用20%乙醇（随意饮用），实验组II的动物接受剂量为42毫克/24小时的头孢氨苄，实验组III的动物接受上述剂量的头孢氨苄和乙醇。10天后，将动物断头并收集胰腺用于电子显微镜下的超微结构检查。所进行的实验表明，乙醇给药10天主要导致胰腺外分泌细胞中核糖体和酶原颗粒数量减少，而头孢氨苄则导致这些细胞器数量增加。乙醇和头孢氨苄同时给药会引起可逆性退行性变化，包括核糖体数量明显减少、许多线粒体肿胀以及细胞内出现髓鞘样结构。
