Zhao S, Liu S, Janier M, Croisille P, Roux J P, Revel D
Laboratoire Creatis-UMR-CNRS 5515, Hopital Cardiovasculaire et Pneumologique Lyon, France.
Chin Med Sci J. 2000 Mar;15(1):29-34.
This study sought to investigate whether low-dose dobutamine-MRI can detect residual myocardial viability in patients with chronic myocardial infarction and, left ventricular dysfunction.
Eleven patients with chronic myocardial infarction and left ventricular dysfunction were employed for identification of viable myocardium by cine-MRI during dobutamine infusion. All patients underwent coronary angiography and left ventriculography, 18FDG-PET, MRI at rest and stress. The systolic wall thickening measured at rest and during stress was compared with the results of 18FDG-PET, respectively.
A significant difference of either dobutamine-induced systolic wall thickening (SWthstress) or dobutamine-induced contractile reserve (deltaSWth = SWthstress - SWthrest) was present between viable and scar regions (1.0 +/- 0.3 versus -0.3 +/- 0.1, P < 0.01; 1.0 +/- 0.3 versus -0.2 +/- 0.2, P < 0.01).
obutamine-induced contractile reserve can be predicted in the regions of akinesia or dyskinesia at rest when systolic wall thickening was > or = 1.0 mm during dobutamine stimulation.
本研究旨在探讨小剂量多巴酚丁胺磁共振成像（MRI）能否检测慢性心肌梗死合并左心室功能障碍患者的残余心肌存活情况。
选取11例慢性心肌梗死合并左心室功能障碍患者，在多巴酚丁胺静脉滴注过程中通过电影MRI识别存活心肌。所有患者均接受冠状动脉造影、左心室造影、18氟脱氧葡萄糖正电子发射断层扫描（18FDG-PET）、静息及负荷状态下的MRI检查。将静息及负荷状态下测得的收缩期室壁增厚分别与18FDG-PET结果进行比较。
存活心肌区域与瘢痕区域之间，多巴酚丁胺诱导的收缩期室壁增厚（SWthstress）或多巴酚丁胺诱导的收缩储备（deltaSWth = SWthstress - SWthrest）均存在显著差异（1.0±0.3对-0.3±0.1，P<0.01；1.0±0.3对-0.2±0.2，P<0.01）。
当多巴酚丁胺刺激时收缩期室壁增厚≥1.0 mm时，可预测静息时运动减弱或运动障碍区域的多巴酚丁胺诱导的收缩储备情况。
