Annerbrink Kristina, Olsson Marie, Melchior Lydia K, Hedner Jan, Eriksson Elias
Department of Pharmacology, Göteborg University, Box 431, SE 405 30 Göteborg, Sweden.
Int J Neuropsychopharmacol. 2003 Mar;6(1):51-6. doi: 10.1017/S1461145703003237.
To elucidate if serotonergic transmission affects respiratory variability, a parameter consistently found increased in patients with panic disorder, we studied the effect of a serotonin synthesis inhibitor, para-chlorophenylalanine (PCPA), on respiratory variability at baseline and during CO2-induced hyperventilation in awake and unrestrained rats. Forty male Wistar rats were given intraperitoneal injections of PCPA (300 mg/kg) or saline 72, 48 and 24 h before registration of respiration in a plethysmograph allowing the animals to move freely. PCPA-treated rats displayed significantly higher tidal volume variability and minute volume variability, both at baseline and during CO2 exposure, compared to controls. The results support the notion that serotonin dysfunction may contribute to the enhanced respiratory variability observed in patients with panic disorder.
为了阐明血清素能传递是否会影响呼吸变异性（这是恐慌症患者中持续发现增加的一个参数），我们研究了血清素合成抑制剂对氯苯丙氨酸（PCPA）在清醒且不受束缚的大鼠基线期以及二氧化碳诱发的过度通气期间对呼吸变异性的影响。在通过体积描记法记录呼吸前72、48和24小时，给40只雄性Wistar大鼠腹腔注射PCPA（300mg/kg）或生理盐水，使动物能够自由活动。与对照组相比，PCPA处理的大鼠在基线期和二氧化碳暴露期间均表现出明显更高的潮气量变异性和分钟通气量变异性。这些结果支持了血清素功能障碍可能导致恐慌症患者呼吸变异性增强这一观点。
