[A 3-amino acid deletion of apolipoprotein E found in 3 Chinese lipoprotein glomerulopathy patients].
作者信息
Chen Yu-qing, Zhang Hong, Zhu Shi-le, Zou Wan-zhong, Wang Mei, Liu Zhang-suo, Wang Hai-yan
机构信息
Department of Nephrology, First Hospital of Peking University, Beijing 100034, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2003 May 10;83(9):774-7.
OBJECTIVE
To analyze the mutation of apolipoprotein E (apoE) gene so as to investigate the pathogenesis of lipoprotein glomerulopathy (LPG).
METHODS
Restriction fragment length polymorphism methods was used to analyze the apoE genotypes of three Chinese patients with LPG and 3 of their relatives. Automated DNA sequencing was performed upon their apoE genes.
RESULTS
A 9-bp deletion in exon 4 of apoE, resulting in a 3-amino acid deletion (residues 142-144-0) was identified.
CONCLUSION
A 3-amino acid deletion of apoE has been discovered which is associated with LPG.
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