绝经后女性接受雌激素治疗后前额叶皮质5-羟色胺2A受体增加。

Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women.

作者信息

Kugaya Akira, Epperson C Neill, Zoghbi Sami, van Dyck Christopher H, Hou Yankun, Fujita Masahiro, Staley Julie K, Garg Pradeep K, Seibyl John P, Innis Robert B

机构信息

Department of Psychiatry, Yale University, New Haven, Conn 06516, USA. akira@

出版信息

Am J Psychiatry. 2003 Aug;160(8):1522-4. doi: 10.1176/appi.ajp.160.8.1522.

DOI:10.1176/appi.ajp.160.8.1522

PMID:12900319

Abstract

OBJECTIVE

This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood.

METHOD

Ten postmenopausal subjects underwent positron emission tomography measurements of 5-HT(2A) receptor binding with [(18)F]deuteroaltanserin before and after estrogen replacement therapy.

RESULTS

5-HT(2A) receptor binding was significantly increased after estrogen replacement therapy in the right prefrontal cortex (right precentral gyrus [Brodmann's area 9], inferior frontal gyrus [Brodmann's area 47], medial frontal gyrus [Brodmann's area 6, 10] and the anterior cingulate cortex [Brodmann's area 32]). In the inferior frontal gyrus [Brodmann's area 44]), receptor up-regulation was correlated with change in plasma estradiol. Verbal fluency and Trail Making Test performance, but not mood, were significantly improved by estrogen without correlation with receptor changes.

CONCLUSIONS

Estrogen increases 5-HT(2A) receptor binding in human prefrontal regions.

摘要

目的

本研究调查了雌激素对绝经后女性脑5-羟色胺2A（5-HT(2A)）受体的影响，以及受体变化与认知和情绪之间是否存在关联。

方法

10名绝经后受试者在雌激素替代治疗前后接受了用[(18)F]氘代阿坦色林进行的5-HT(2A)受体结合的正电子发射断层扫描测量。

结果

雌激素替代治疗后，右侧前额叶皮质（右侧中央前回[布罗德曼区9]、额下回[布罗德曼区47]、额内侧回[布罗德曼区6、10]和前扣带回皮质[布罗德曼区32]）的5-HT(2A)受体结合显著增加。在额下回[布罗德曼区44]），受体上调与血浆雌二醇的变化相关。雌激素显著改善了语言流畅性和连线测验表现，但未改善情绪，且与受体变化无关。