Peibin Yue, Shude Yang, Changzhi Huang
Cancer Institute & Hospital, CAMS & PUMC, Beijing 100021.
Chin Med Sci J. 2002 Dec;17(4):251-6.
Heat shock protein gp96 is a highly conserved and monomorphic glycoprotein in the endoplasmic reticulum. It functions as molecular chaperone and can associate with a variety of antigenic peptides noncovalently in vivo and in vitro. Recent studies have indicated that gp96 molecules participate in major histocompatibility complex class I-restricted antigen presentation pathway. Immunization of mice with gp96 preparations isolated from cancer cells can elicit a cancer-specific protective T cell immune response that is recallable, which is a prerequisite for gp96 as a therapeutic vaccine against cancers. The immunogenicity of gp96 molecules has been attributed to the antigenic peptides associated with them. These phenomena provide a new pathway for cancer immunotherapy. The mechanism that the gp96-peptide complex induces specific immune response and the explorations for gp96-peptide complex as a therapeutic cancer vaccine are reviewed.
热休克蛋白gp96是内质网中一种高度保守且单态的糖蛋白。它作为分子伴侣发挥作用，在体内和体外均可与多种抗原肽非共价结合。最近的研究表明，gp96分子参与主要组织相容性复合体I类限制的抗原呈递途径。用从癌细胞中分离的gp96制剂免疫小鼠可引发可回忆的癌症特异性保护性T细胞免疫反应，这是gp96作为抗癌治疗性疫苗的先决条件。gp96分子的免疫原性归因于与其相关的抗原肽。这些现象为癌症免疫治疗提供了一条新途径。本文综述了gp96-肽复合物诱导特异性免疫反应的机制以及对gp96-肽复合物作为治疗性癌症疫苗的探索。
