Yin Yafu, Ren Yan, Li Yaming
Department of Nuclear Medicine, the First Affiliated Hospital, China Medical University, Shenyang 110001.
Chin Med Sci J. 2003 Mar;18(1):31-5.
To explore the correlations between the occurrence and severity of neglect and the region, range or extent of the decrease in regional cerebral blood flow (rCBF).
Nineteen dextromanual patients who were diagnosed as unilateral stroke clinically and hemispatial neglect by a neglect test battery received single photon emission computed tomography (SPECT) scans.
On images, the damages of patients with neglect were seen most frequently in the frontal cortex, and then in turn in the parietal cortex, occipital cortex, temporal cortex, basal ganglia and thalamus. Most patients with neglect had two or more regions damaged. The most significant region was temporal-parietal-occipital (TPO) junction. The correlation coefficient between rCBF and the severity of neglect was -0.34 (t = -1.5, P > 0.05), and that between the decrease percentage of rCBF and the severity of neglect was 0.34 (t = 1.47, P > 0.05). The correlation coefficients between the range, number of foci, the flow deficit size and the severity of neglect were 0.71 (t = 4.13, P < 0.01), 0.70 (t = 4.07, P < 0.01) and 0.64 (t = 3.40, P < 1.01), respectively.
The severity of neglect correlates with rCBF and the decrease percentage of rCBF insignificantly, but correlates positively with the range, number of foci and the flow deficit size significantly. Hemispatial neglect is caused by the damage of multiple sites and combined damage results in more severe neglect.
探讨疏忽的发生及严重程度与局部脑血流量（rCBF）降低的区域、范围或程度之间的相关性。
19例经临床诊断为单侧中风且通过疏忽测试组判定为半侧空间疏忽的右利手患者接受了单光子发射计算机断层扫描（SPECT）。
在图像上，疏忽患者的损伤最常出现在额叶皮质，其次依次为顶叶皮质、枕叶皮质、颞叶皮质、基底神经节和丘脑。大多数疏忽患者有两个或更多区域受损。最显著的区域是颞-顶-枕（TPO）交界处。rCBF与疏忽严重程度之间的相关系数为-0.34（t = -1.5，P > 0.05），rCBF降低百分比与疏忽严重程度之间的相关系数为0.34（t = 1.47，P > 0.05）。范围、病灶数量、血流缺损大小与疏忽严重程度之间的相关系数分别为0.71（t = 4.13，P < 0.01）、0.70（t = 4.07，P < 0.01）和0.64（t = 3.40，P < 0.01）。
疏忽的严重程度与rCBF及rCBF降低百分比无显著相关性，但与范围、病灶数量和血流缺损大小呈显著正相关。半侧空间疏忽是由多个部位的损伤引起的，联合损伤会导致更严重的疏忽。
