Das Atze T, Zhou Xue, Vink Monique, Klaver Bep, Berkhout Ben
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands.
Expert Rev Vaccines. 2002 Oct;1(3):293-301. doi: 10.1586/14760584.1.3.293.
To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.
为了控制人类免疫缺陷病毒在全球的传播，迫切需要一种安全有效的预防性疫苗。对猿猴免疫缺陷病毒的研究表明，减毒活病毒可作为一种有效的疫苗，但人们对这种疫苗病毒的安全性产生了严重担忧。我们提出一种条件性活病毒，其复制可随意开启和关闭，作为一种新型的HIV疫苗方法。
