Smith B S, Walker N J
Department of Physical Therapy, Wichita State University, Kansas 67208.
Teratology. 1992 Dec;46(6):583-98. doi: 10.1002/tera.1420460608.
The lenses and head mesenchyme of two 11-gestational day trisomy 1 mouse embryos and a normal littermate were examined using transmission electron microscopy (TEM). One trisomic embryo had a small lens with a lens stalk; the other was aphakic. The resolution available with TEM allowed detailed evaluation of cell organelles, spatial relationships and the intra- and extracellular structural environment of the lens and head mesenchyme in normal and aneuploid embryos. Differences in fine structure between normal and trisomic lenses included (1) type of epithelium, (2) size of intercellular lacunae, and (3) activity of Golgi complexes. Differences in mesenchyme included (1) the number and size of cytoplasmic extensions, (2) shape of the cells, and (3) reduced endotheliomesenchymal interactions.
使用透射电子显微镜（TEM）对两个妊娠11天的13三体小鼠胚胎和一个正常同窝小鼠的晶状体及头部间充质进行了检查。一个三体胚胎有一个带晶状体柄的小晶状体；另一个无晶状体。TEM的分辨率能够详细评估正常和非整倍体胚胎中晶状体及头部间充质的细胞器、空间关系以及细胞内和细胞外结构环境。正常和三体晶状体之间的细微结构差异包括：（1）上皮类型；（2）细胞间腔隙大小；（3）高尔基体复合体的活性。间充质的差异包括：（1）细胞质突起的数量和大小；（2）细胞形状；（3）内皮-间充质相互作用减弱。
