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成人用甲肝乙肝联合疫苗在老年人中的免疫原性：一项批判性分析。

Immunogenicity of Twinrix in older adults: a critical analysis.

作者信息

Stoffel Michel, Lievens Marc, Dieussaert Ilse, Martin Isabelle, André Francis

机构信息

GlaxoSmithKline Biologicals, Rixensart, Belgium.

出版信息

Expert Rev Vaccines. 2003 Feb;2(1):9-14. doi: 10.1586/14760584.2.1.9.

DOI:10.1586/14760584.2.1.9
PMID:12901592
Abstract

Twinrix (GlaxoSmithKline Biologicals, Rixensart, Belgium) is the first combined vaccine to provide protection against both hepatitis A and B. This review presents a critical analysis of antibody responses stratified by age following vaccination with Twinrix in 264 adults aged above 40 years. A month after completion of a 0-, 1-, 6-month vaccination schedule with Twinrix, a good response was observed for both anti-HAV and anti-HBs serum antibodies, suggesting that is an effective vaccine in older adults.

摘要

安尔宝（葛兰素史克生物制品公司，比利时里克森萨特）是首款可同时预防甲型和乙型肝炎的联合疫苗。本综述对264名40岁以上成年人接种安尔宝疫苗后按年龄分层的抗体反应进行了批判性分析。在完成0、1、6月的安尔宝疫苗接种程序一个月后，观察到抗甲型肝炎病毒（anti-HAV）和抗乙型肝炎表面抗原（anti-HBs）血清抗体均有良好反应，表明该疫苗在老年人中有效。

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