内源性一氧化碳在内毒素休克中的作用。
Role of endogenous carbon monoxide in endotoxin shock.
作者信息
Yuan S, Huaqiang L, Jie P, Shiwen Q, Feng P, Dongbo J, Jigao S
机构信息
Department of Pediatrics, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
出版信息
Chin Med Sci J. 2000 Jun;15(2):98-102.
OBJECTIVE
To study the role of endogenous carbon monoxide (CO) in endotoxin shock.
METHODS
The changes of CO levels and the effects of zinc protoporphyrin IX (ZnPP), an inhibitor of heme-oxygenase (HO), in endotoxin shock and the efficacy of hemin, an inducer of HO were investigated.
RESULTS
The plasma CO levels were found to be significantly increased during the course of endotoxin shock. Injection of ZnPP was shown to abrogate the endotoxin-induced hypotension and metabolic derangements markedly. Administration of hemin to healthy rabbits revealed the hypotension and metabolic derangements similar to the animals given endotoxin.
CONCLUSION
CO is a newly found endogenously produced mediator which may play an important role in the pathogenesis of endotoxin shock.
目的
研究内源性一氧化碳（CO）在内毒素休克中的作用。
方法
研究内毒素休克过程中CO水平的变化以及血红素加氧酶（HO）抑制剂原卟啉锌（ZnPP）的作用，同时研究HO诱导剂血红素的疗效。
结果
在内毒素休克过程中，血浆CO水平显著升高。注射ZnPP可明显消除内毒素诱导的低血压和代谢紊乱。给健康兔注射血红素后，出现了与给予内毒素的动物相似的低血压和代谢紊乱。
结论
CO是一种新发现的内源性介质，可能在内毒素休克的发病机制中起重要作用。
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