Xu Hui, Shimizu Yoshinaka, Niki Takayuki, Nagasaka Hiroshi, Kawamura Hiroshi, Ooya Kiyoshi
Division of Oral Pathology, Department of Oral Medicine and Bioregulation, Tohoku University Graduate School of Dentistry, Sendai, Japan.
J Oral Pathol Med. 2003 Sep;32(8):499-501. doi: 10.1034/j.1600-0714.2003.00171.x.
This article describes an unusual case of pleomorphic adenoma arising in the submandibular salivary glands that was associated with marked ossification. CT scan showed an irregular high-density mass in the left submandibular region. Histologic examination of the resected mass revealed a well-circumscribed pleomorphic adenoma with chondroid tissue intermingled with glandular and trabecular epithelial components. Irregularly formed osseous tissue was present in the chondroid tissue. The osseous tissue showed bone matrix on von Kossa's staining. Alkaline phosphatase expression was restricted to the vicinity of osseous tissue. Tartrate-resistant acid phosphatase-positive osteoclasts were observed at the periphery of the osseous tissue. CD34 staining demonstrated many microvascular vessels in both the chondroid and osseous tissues. We conclude the osseous tissue in pleomorphic adenoma was bone in nature, and via the process of endochondral ossification most likely depended on angiogenesis.
本文描述了一例发生于下颌下唾液腺的多形性腺瘤的罕见病例，该病例伴有明显骨化。CT扫描显示左下颌下区域有一不规则高密度肿块。对切除肿块的组织学检查显示为边界清楚的多形性腺瘤，软骨样组织与腺性及小梁状上皮成分混合存在。在软骨样组织中可见不规则形成的骨组织。骨组织在冯·科萨染色下显示有骨基质。碱性磷酸酶表达局限于骨组织附近。在骨组织周边观察到抗酒石酸酸性磷酸酶阳性的破骨细胞。CD34染色显示软骨样组织和骨组织中均有许多微血管。我们得出结论，多形性腺瘤中的骨组织本质上是骨，并且通过软骨内成骨过程很可能依赖于血管生成。
