小鼠4号染色体上的D4Mit12基因座对γ射线诱导和N-甲基-N-亚硝基脲诱导的胸腺淋巴瘤均具有易感性。
The D4Mit12 locus on mouse chromosome 4 provides susceptibility to both gamma-ray-induced and N-methyl-N-nitrosourea-induced thymic lymphomas.
作者信息
Sato Hiroki, Tamura Yasushi, Ochiai Yukie, Kodama Yasumitsu, Hatakeyama Katsuyoshi, Niwa Ohtsura, Kominami Ryo
机构信息
Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8122, Asahimachi, Japan.
出版信息
Cancer Sci. 2003 Aug;94(8):668-71. doi: 10.1111/j.1349-7006.2003.tb01500.x.
Low-penetrance genes control different susceptibilities to gamma-ray-induced thymic lymphomas in mouse strains. Our previous genetic analyses with backcross mice between BALB/c and MSM strains and congenic lines localized one such gene near the D4Mit12 locus on chromosome 4. N-Methyl-N-nitrosourea (MNU) is a guanine base-alkylating agent and differs from gamma-radiation in its mechanism of mutagenic action. Accordingly, in this study, we examined whether or not the locus also provides susceptibility to MNU-induced thymic lymphomas using 84 offsprings derived from congenic mice for D4Mit12. Association analysis provided a suggestive linkage at D4Mit12 (P = 0.0075) and the linkage was sustained by the peak of likelihood ratio statistical values being at the same position as that for the gamma-ray-induced lymphomas. The results strongly suggest that the BALB/c allele near D4Mit12 is associated with susceptibility to lymphomas induced by two carcinogenic agents having different mechanisms of mutagenic action.
低 penetrance 基因控制小鼠品系对γ射线诱导的胸腺淋巴瘤的不同易感性。我们之前用 BALB/c 和 MSM 品系之间的回交小鼠以及近交系进行的遗传分析将一个这样的基因定位在 4 号染色体上的 D4Mit12 位点附近。N-甲基-N-亚硝基脲（MNU）是一种鸟嘌呤碱基烷基化剂，其诱变作用机制与γ射线不同。因此，在本研究中，我们使用来自 D4Mit12 近交系小鼠的 84 只后代，研究该位点是否也对 MNU 诱导的胸腺淋巴瘤具有易感性。关联分析在 D4Mit12 处提供了一个提示性连锁（P = 0.0075），并且似然比统计值的峰值位于与γ射线诱导的淋巴瘤相同的位置，从而维持了这种连锁。结果强烈表明，D4Mit12 附近的 BALB/c 等位基因与由两种具有不同诱变作用机制的致癌剂诱导的淋巴瘤易感性相关。
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