Tadaki Tohru, Kamiyama Ryosuke, Okamura Hiro-Oki, Ohtani Iwao
Department of Otolaryngology, Fukushima Medical University, Fukushima, Tokyo, Japan.
J Laryngol Otol. 2003 Jul;117(7):580-3. doi: 10.1258/002221503322113094.
The purpose of this study was to define the histopathological changes in the temporal bone of a fetus with trisomy 18 syndrome, a stillborn due to perosplanchnia. Several anomalies were found including malformation of the auditory ossicles, residual mesenchyme in the middle ear, aberrant tensor tympani muscle, absence of stapedial tendon, aberrant lateral ampullary nerve and wide endolymphatic sinus. The incus body was deformed and separated from the long process by connective tissue and monocrural stapes was noted in the right ear. Three-dimensional reconstruction images provided a clear view of the auditory ossicle malformation. The abnormal findings in our case indicate that ear anomalies in this syndrome might be derived from the component around the first and second branchial arches.
本研究的目的是确定一名因内脏外翻而死产的18三体综合征胎儿颞骨的组织病理学变化。发现了几种异常情况，包括听小骨畸形、中耳残留间充质、异常的鼓膜张肌、镫骨肌腱缺失、异常的外侧壶腹神经和宽内淋巴窦。砧骨体变形并通过结缔组织与长突分离，右耳可见单脚镫骨。三维重建图像清晰显示了听小骨畸形。我们病例中的异常发现表明，该综合征中的耳部异常可能源于第一和第二鳃弓周围的结构。
