Clark Ian A, Rockett Kirk A, Burgner David
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia.
Trends Parasitol. 2003 Aug;19(8):335-7. doi: 10.1016/s1471-4922(03)00147-8.
The unresolved and complex relationship between nitric oxide and falciparum malaria is reflected in recent genetic and immunohistochemical studies in African children. Different genetic associations, perhaps geographically distinctive, are seen between genetic variants of the inducible nitric oxide gene and various disease manifestations in African populations. The picture might not be complete without considering the emerging roles of carbon monoxide, another endogenous gaseous mediator with similar effects to those of nitric oxide. Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood.
一氧化氮与恶性疟原虫之间尚未解决且复杂的关系，在近期针对非洲儿童的基因和免疫组织化学研究中有所体现。在非洲人群中，诱导型一氧化氮基因的不同遗传变异与各种疾病表现之间存在不同的遗传关联，这些关联可能具有地域差异。如果不考虑一氧化碳（另一种与一氧化氮作用相似的内源性气体介质）新出现的作用，情况可能并不完整。只有对热带非洲各地的基因比较进行研究，并结合全身炎症事件中新发现的复杂性，才能理解这种关系。
