一名2岁儿童因摄入最多3片非那吡啶导致高铁血红蛋白血症：病例报告及文献复习

Methemoglobinemia due to ingestion of at most three pills of pyridium in a 2-year-old: case report and review.

作者信息

Gold Nina A, Bithoney William G

机构信息

Child Protection and Safety Center, Pediatric Emergency Department, St. Joseph's Regional Medical Center, St. Joseph's Children's Hospital, Paterson, New Jersey, USA.

出版信息

J Emerg Med. 2003 Aug;25(2):143-8. doi: 10.1016/s0736-4679(03)00162-8.

DOI:10.1016/s0736-4679(03)00162-8

PMID:12901999

Abstract

Pyridium (phenazopyridine HCl) is a commonly prescribed medication in the treatment of urinary tract infections and is known to cause methemoglobinemia in excessive doses. We report the case of a 2-year-old child who ingested a maximum of three 200-mg tablets (approximately 50 mg/kg) of pyridium and yet developed cyanosis and methemoglobinemia (29.1%), resulting in methylene blue therapy. We urge physicians to consider a period of observation (4-6 h) or to obtain methemoglobin levels in children who ingest even a small number of pyridium tablets because this can represent a toxic dose in a small child.

摘要

非那吡啶（盐酸非那吡啶）是治疗尿路感染的常用处方药，已知过量服用会导致高铁血红蛋白血症。我们报告了一名2岁儿童的病例，该儿童最多服用了三片200毫克的非那吡啶片剂（约50毫克/千克），但仍出现了紫绀和高铁血红蛋白血症（29.1%），因此接受了亚甲蓝治疗。我们敦促医生对即使只摄入少量非那吡啶片剂的儿童进行一段时间的观察（4 - 6小时）或检测高铁血红蛋白水平，因为这对幼儿来说可能是有毒剂量。