Engebretsen Kristin M, Harris Carson R, Wood James E
Clinical Toxicology Service, Emergency Medicine Department, Regions Hospital, St. Paul, Minnesota, USA.
J Emerg Med. 2003 Aug;25(2):163-6. doi: 10.1016/s0736-4679(03)00164-1.
A 31-year-old man ingested 400 mg of citalopram (Celexa) after an argument with his parents and girlfriend 13 h before presentation. Paramedics witnessed the patient having a generalized clonic seizure. The electrocardiogram (EKG) revealed a wide QRS complex, prolongation of the QTc interval, and left bundle branch pattern. He was treated with sodium bicarbonate with resolution of these changes. The patient was continued on a sodium bicarbonate infusion and demonstrated no further EKG abnormalities. Sodium bicarbonate should be considered as a treatment modality in patients with EKG abnormalities of prolongation of QRS or QTc interval after citalopram overdose.
一名31岁男性在与父母及女友争吵后13小时就诊前摄入了400毫克西酞普兰（喜普妙）。护理人员目睹患者发生全身性阵挛性惊厥。心电图（EKG）显示QRS波群增宽、QTc间期延长及左束支传导阻滞图形。给予碳酸氢钠治疗后这些改变消失。患者继续接受碳酸氢钠静脉输注，心电图未再出现异常。对于西酞普兰过量后出现QRS或QTc间期延长的心电图异常患者，应考虑将碳酸氢钠作为一种治疗方式。
