Thomas Carlton W, Lowry Philip W, Franklin Curtis L, Weaver Amy L, Myhre Gennett M, Mays Dennis C, Tremaine William J, Lipsky James J, Sandborn William J
Division of Gastroenterology and Hepatology, Division of Clinical Pharmacology, and Section of Biostatistics, Mayo Clinic, Rochester, MN 55905, U.S.A.
Inflamm Bowel Dis. 2003 Jul;9(4):237-45. doi: 10.1097/00054725-200307000-00004.
Mean corpuscular volume may correlate with erythrocyte 6-thioguanine nucleotide concentrations in patients treated with azathioprine and 6-mercaptourine. We conducted a study of 166 patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine to determine the relationship between mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentrations, disease activity as measured by the Inflammatory Bowel Disease Questionnaire (active disease <170, remission >170), and leukopenia. Blood was submitted for mean corpuscular volume, whole blood 6-thioguanine nucleotide concentration, and leukocyte count. The mean +/- SD mean corpuscular volume during treatment was 94.7 +/- 6.6 fL and the mean +/- SD change in mean corpuscular volume was 7.5 +/- 6.3 fL. There were significant correlations between mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentration (r(s) = 0.33, p < 0.001) and between change from baseline in mean corpuscular volume and erythrocyte 6-thioguanine nucleotide concentration (r(s) = 0.26, p = 0.001). There was no correlation between Inflammatory Bowel Disease Questionnaire scores and mean corpuscular volume values (r(s) = 0.01, p = 0.94). The mean corpuscular volume values in 55 patients with active disease and 111 patients in remission were similar (95.1 vs. 94.5 fL, p = 0.57). There was a weak negative correlation between the mean corpuscular volume and the leukocyte count, (r(s) = -0.18, p = 0.022). In patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine, mean corpuscular volume and change from baseline in mean corpuscular volume correlated with erythrocyte 6-thioguanine nucleotide concentrations and negatively with leukocyte counts, but did not correlate with disease activity as measured by the Inflammatory Bowel Disease Questionnaire. Measurement of mean corpuscular volume is a simple and inexpensive alternative to measurement of 6-thioguanine nucleotide concentrations in patients treated with azathioprine or 6-mercaptopurine.
在接受硫唑嘌呤和6-巯基嘌呤治疗的患者中，平均红细胞体积可能与红细胞6-硫鸟嘌呤核苷酸浓度相关。我们对166例接受硫唑嘌呤或6-巯基嘌呤治疗的炎症性肠病患者进行了一项研究，以确定平均红细胞体积与红细胞6-硫鸟嘌呤核苷酸浓度、通过炎症性肠病问卷测量的疾病活动度（活动期疾病<170，缓解期>170）以及白细胞减少之间的关系。采集血液以检测平均红细胞体积、全血6-硫鸟嘌呤核苷酸浓度和白细胞计数。治疗期间平均红细胞体积的均值±标准差为94.7±6.6 fL，平均红细胞体积的均值±标准差变化为7.5±6.3 fL。平均红细胞体积与红细胞6-硫鸟嘌呤核苷酸浓度之间存在显著相关性（r(s)=0.33，p<0.001），且平均红细胞体积相对于基线的变化与红细胞6-硫鸟嘌呤核苷酸浓度之间也存在显著相关性（r(s)=0.26，p=0.001）。炎症性肠病问卷评分与平均红细胞体积值之间无相关性（r(s)=0.01，p=0.94）。55例活动期疾病患者和111例缓解期患者的平均红细胞体积值相似（95.1对94.5 fL，p=0.57）。平均红细胞体积与白细胞计数之间存在弱负相关性（r(s)=-0.18，p=0.022）。在接受硫唑嘌呤或6-巯基嘌呤治疗的炎症性肠病患者中，平均红细胞体积及其相对于基线的变化与红细胞6-硫鸟嘌呤核苷酸浓度相关，与白细胞计数呈负相关，但与通过炎症性肠病问卷测量的疾病活动度无关。对于接受硫唑嘌呤或6-巯基嘌呤治疗的患者，测量平均红细胞体积是一种简单且廉价的替代方法，可用于替代测量6-硫鸟嘌呤核苷酸浓度。
