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利妥昔单抗(一种抗CD20单克隆抗体)成功治疗难治性低度十二指肠淋巴瘤。

Successful treatment of refractory low grade duodenal lymphoma with rituximab, an anti-CD20 monoclonal antibody.

作者信息

Ahmed Shazia, Singh Aman, Krauss John, Wentz Tracey, Gunaratnam Naresh T

机构信息

Department of Internal Medicine, St. Joseph Mercy Hospital, Ann Arbor, Michigan 48195, USA.

出版信息

Am J Clin Oncol. 2003 Aug;26(4):408-10. doi: 10.1097/01.COC.0000026485.57632.1E.

DOI:10.1097/01.COC.0000026485.57632.1E
PMID:12902896
Abstract

Duodenal lymphoma accounts for a small percentage of gastrointestinal tumors and has a very poor prognosis. The majority of patients have little or no cure with limited time of remission. Median survival is 5 to 10 years, and most patients die of lymphoma, its complications, or complications of therapy. We report a patient with lymphoma refractory to treatment with cyclophosphamide, vincristine, and prednisone, who was successfully treated with rituximab, a CD-20 monoclonal antibody.

摘要

十二指肠淋巴瘤在胃肠道肿瘤中占比很小,预后很差。大多数患者几乎无法治愈或治愈希望渺茫,缓解期有限。中位生存期为5至10年,大多数患者死于淋巴瘤、其并发症或治疗并发症。我们报告了一名对环磷酰胺、长春新碱和泼尼松治疗无效的淋巴瘤患者,该患者用CD-20单克隆抗体利妥昔单抗成功治愈。

相似文献

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Successful treatment of refractory low grade duodenal lymphoma with rituximab, an anti-CD20 monoclonal antibody.利妥昔单抗(一种抗CD20单克隆抗体)成功治疗难治性低度十二指肠淋巴瘤。
Am J Clin Oncol. 2003 Aug;26(4):408-10. doi: 10.1097/01.COC.0000026485.57632.1E.
2
[Efficacy of rituximab-containing salvage regimens on relapsed or refractory B-cell non-Hodgkin's lymphoma].含利妥昔单抗的挽救方案对复发或难治性B细胞非霍奇金淋巴瘤的疗效
Ai Zheng. 2006 Apr;25(4):486-9.
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The therapeutic use of rituximab in non-Hodgkin's lymphoma.利妥昔单抗在非霍奇金淋巴瘤中的治疗应用。
Eur J Haematol Suppl. 2007 Jan(67):5-14. doi: 10.1111/j.1600-0609.2006.00789.x.
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Rituximab and its role as maintenance therapy in non-Hodgkin lymphoma.利妥昔单抗及其在非霍奇金淋巴瘤维持治疗中的作用。
Expert Rev Anticancer Ther. 2007 Mar;7(3):257-73. doi: 10.1586/14737140.7.3.257.
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[Clinical trial of the monoclonal antibody drug mabthera (Rituximab) in the treatment of non-Hodgkin lymphoma].单克隆抗体药物美罗华(利妥昔单抗)治疗非霍奇金淋巴瘤的临床试验
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Prolonged clinical and molecular remission in patients with low-grade or follicular non-Hodgkin's lymphoma treated with rituximab plus CHOP chemotherapy: 9-year follow-up.利妥昔单抗联合CHOP化疗治疗低度或滤泡性非霍奇金淋巴瘤患者的长期临床和分子缓解:9年随访
J Clin Oncol. 2004 Dec 1;22(23):4711-6. doi: 10.1200/JCO.2004.04.020. Epub 2004 Oct 13.
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[Treatment options in non-Hodgkin lymphomas].[非霍奇金淋巴瘤的治疗选择]
Rev Prat. 2010 Jan 20;60(1):69-74.
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Use of rituximab in combination with conventional chemotherapy for the treatment of non-Hodgkin's lymphoma of the head and neck.利妥昔单抗联合传统化疗用于治疗头颈部非霍奇金淋巴瘤。
In Vivo. 2009 May-Jun;23(3):475-8.
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Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention.利妥昔单抗(美罗华,抗CD20单克隆抗体)在非霍奇金淋巴瘤中调节的细胞和分子信号转导途径:对化疗增敏和治疗干预的影响。
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[A three-year experience with use of mabthera (rituximab) in treatment of indolent non-Hodgkin's disease refractory to standard chemotherapy].[美罗华(利妥昔单抗)治疗对标准化疗耐药的惰性非霍奇金淋巴瘤的三年经验]
Vopr Onkol. 2004;50(4):421-5.

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