基于三联体家庭的5-羟色胺转运体基因多态性与精神分裂症的传递不平衡检验
[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios].
作者信息
Sun Wei-wei, Fan Jin-bo, Qian Xue-qing, Tang Jun-xia, Xing Yang-lin, Shi Jian-guo, Zhu Shao-min, Liu Hui-jun, Gu Niu-fan, Feng Guo-yin, He Lin
机构信息
Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Aug;20(4):342-4.
OBJECTIVE
To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.
METHODS
A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).
RESULTS
No significantly preferential transmission of any allele was detected from both polymorphisms investigated.
CONCLUSION
The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
目的
研究5-羟色胺转运体基因的两个多态性（内含子可变数目串联重复序列和5-羟色胺转运体基因启动子区多态性）与精神分裂症之间的关系。
方法
对独立收集自中国上海、西安和吉林地区的314个精神分裂症三联体样本进行传递/不平衡检验（TDT），以分析这些多态性。
结果
在所研究的两个多态性中，均未检测到任何等位基因的显著优先传递。
结论
结果表明，5-羟色胺转运体基因不太可能对汉族人群精神分裂症易感性有主要影响。
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