Kaneko Toshiyuki, Aso Mariko, Nakamura Morihide, Matsui Yasuhiro, Koga Noboru, Suemune Hiroshi
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Nucleic Acids Res Suppl. 2002(2):139-40. doi: 10.1093/nass/2.1.139.
Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
