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Preparation and enzymatic recognition of guanine lesions induced by nitrogen oxides.

作者信息

Masaoka A, Terato H, Honsho A, Ohyama Y, Suzuki T, Yamada M, Makino K, Ide H

机构信息

Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.

出版信息

Nucleic Acids Symp Ser. 2000(44):87-8. doi: 10.1093/nass/44.1.87.

DOI:10.1093/nass/44.1.87
PMID:12903281
Abstract

Xanthine (Xan) and oxanine (Oxa) are the major deamination products of guanine formed by the treatment with nitrogen oxides (e.g., NO and HNO2). In this study, 2'-deoxyribonucleoside 5'-triphosphates of Xan and Oxa were prepared by the NaNO2 treatment of dGTP. These modified nucleotides were incorporated into oligonucleotides by DNA polymerase reactions. The repair activities of various DNA N-glycosylases for Xan and Oxa were examined using these substrates.

摘要

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