核苷酸衍生物和糖核苷酸类似物作为糖基转移酶抑制剂的评估。
Evaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases.
作者信息
Osumi K, Kawauchi N, Lu A H, Hindsgaul O, Palcic M M
机构信息
Research Department, Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan.
出版信息
Nucleic Acids Symp Ser. 2000(44):89-90. doi: 10.1093/nass/44.1.89.
PMID:12903282
Abstract
The inhibition of glycosyltransferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.
摘要
使用单磷酸尿苷衍生物和二磷酸尿苷糖类似物研究了糖基转移酶的抑制作用。核苷部分的修饰导致了糖基转移酶的选择性抑制。
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