[表皮生长因子受体在妊娠滋养细胞肿瘤中的表达]
[Expression of epidermal growth factor receptor in gestational trophoblastic tumours].
作者信息
Xiang Y, Li Z, Cui Q, Yang X, Song H
机构信息
Department of Gynecology and Obstetrics, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Dec;22(6):555-7.
OBJECTIVE
To investigate the expression of epidermal growth factor receptor (EGFR) in gestational trophoblastic tumours and its clinical significance.
METHODS
Placentas of 10 normal early pregnancies, 20 molar pregnancies, 10 samples from invasive mole and 8 samples of choriocarcinoma were used for the study. EGFR expression was evaluated by immunohistochemistry using monoclonal antibody.
RESULTS
EGFR was expressed both in normal chorionic villi and tissues of trophoblastic tumours. EGFR was expressed more strongly in normal chorionic villi and non-malignant transformed hydatidiform mole than in malignant transformed molar pregnancies and malignant trophoblastic tumours (P < 0.05). Univariate and multivariate analysis indicated that EGFR immunostaining intensity was significantly related to the clinical stage in malignant trophoblastic tumours (P = 0.026, OR = 9.874).
CONCLUSION
EGFR expression could be used as an index for prediction of malignant transformation of hydatidiform mole and staging of malignant trophoblastic tumours.
目的
探讨表皮生长因子受体（EGFR）在妊娠滋养细胞肿瘤中的表达及其临床意义。
方法
选取10例正常早孕胎盘、20例葡萄胎、10例侵蚀性葡萄胎组织及8例绒毛膜癌组织进行研究。采用单克隆抗体免疫组化法评估EGFR表达。
结果
EGFR在正常绒毛及滋养细胞肿瘤组织中均有表达。EGFR在正常绒毛及未恶变的葡萄胎中表达较恶变的葡萄胎妊娠及恶性滋养细胞肿瘤更强（P<0.05）。单因素及多因素分析表明，EGFR免疫染色强度与恶性滋养细胞肿瘤的临床分期显著相关（P = 0.026，OR = 9.874）。
结论
EGFR表达可作为预测葡萄胎恶变及恶性滋养细胞肿瘤分期的指标。
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