Pusceddu C, Mameli S, Pili A, Podda G
Servizio di Radiodiagnostica, Ospedale Oncologico A Businco, ASL 8, UO Terapia Antalgica.
Tumori. 2003 Jul-Aug;89(4 Suppl):286-91.
To verify the effectiveness and the incidence of complication in the transcutaneal celiac plexus block with CT-guided in the patient with intractable upper abdominal cancer, using alcoholic solutions to different concentrations (50% and 96%), previous insertion of the peridural catheter. From December 1997 to June 2002, studies were carried out on 24 patients with CT-guided percutaneous coeliac plexus neurolysis including 17 men and 7 women with inoperable abdominal malignancy and two with chronic pancreatitis. The patients were affected by very intense pain controllable only with high doses of analgesic narcotics. Before the procedure a catheter was installed in the peridurale space between L1-T12. To avoid general anesthesia, 40 mL of marcaine 0.5% was injected to relieve the back pain sometimes reported after the neurolysis, caused by the diffusion of alcohol in the coeliac plexus. This technique requires a posterior percutaneous procedural transaortic approach CT scan guided, to determine the correct position of the needle tips and the spread of neurolytic solution (40 mL of 96% + 3 mL of contrast medium) around the origin of the coeliac trunk's anatomical center of the plexus. The first 10 patients have received 40 mL of 50% ethyl alcohol + 3 mL of contrast medium. To evaluate the rate of the analgesia relief, a visual analogue pain score (VAS) was used before and 48 hours after the neurolysis. The percutaneous neurolysis of the celiac plexus is useful to relieve the pain in patients affected by cancer developing in upper abdomen. The CT-scan guide of the needle allows an omogeneous distribution of the contrast medium. The insertion of the peridural catheter made a complete analgesia and reduced the incidence of complications. Our method provided an excellent control of the pain in all patients. In our experience the pain relief was almost complete in patients treated with 96% ethyl alcohol solution (VAS from 8 before the treatment to 1, 48 hours after the treatment). The alcohol administered in elevated concentrations (96%), does not increase the incidence of complications.
为验证在难治性上腹部癌症患者中,采用不同浓度(50%和96%)酒精溶液并预先置入硬膜外导管,经CT引导进行经皮腹腔神经丛阻滞的有效性及并发症发生率。1997年12月至2002年6月,对24例经CT引导的经皮腹腔神经丛松解术患者进行了研究,其中包括17例男性和7例女性,患有无法手术的腹部恶性肿瘤,2例患有慢性胰腺炎。这些患者遭受非常剧烈的疼痛,仅用高剂量的镇痛麻醉剂才能控制。在手术前,在L1 - T12之间的硬膜外间隙置入一根导管。为避免全身麻醉,注射40 mL 0.5%的布比卡因以缓解有时在神经松解术后因酒精在腹腔神经丛扩散而引起的背痛。该技术需要经皮后路经主动脉途径CT扫描引导,以确定针尖的正确位置以及神经溶解溶液(40 mL 96%酒精 + 3 mL造影剂)在腹腔干起源周围神经丛解剖中心的扩散情况。前10例患者接受了40 mL 50%乙醇 + 3 mL造影剂。为评估镇痛缓解率,在神经松解术前和术后48小时使用视觉模拟疼痛评分(VAS)。经皮腹腔神经丛松解术有助于缓解上腹部癌症患者的疼痛。针的CT扫描引导可使造影剂均匀分布。硬膜外导管的置入实现了完全镇痛并降低了并发症发生率。我们的方法在所有患者中均实现了对疼痛的良好控制。根据我们的经验,用96%乙醇溶液治疗的患者疼痛几乎完全缓解(治疗前VAS为8,治疗后48小时为1)。高浓度(96%)酒精的使用并未增加并发症发生率。