Maxwell Lynne G, Tobias Joseph D, Cravero Joseph P, Malviya Shobha
Children's Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, 9th Floor Main, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.
Expert Opin Drug Saf. 2003 Mar;2(2):167-94. doi: 10.1517/14740338.2.2.167.
The application of sedation/analgesia in paediatric patients is rapidly expanding as less invasive, non-operative techniques of diagnosis and treatment are applied to the paediatric population. Medical providers who are asked to provide sedation may include radiologists, paediatricians, nurses and emergency physicians, as well as anaesthesiologists and intensive care physicians. At the same time, the range of drugs used in these settings has expanded considerably. As there is no single drug fulfilling the criteria for the ideal sedative (rapid-onset, rapid recovery, no adverse effects, immobility appropriate to procedure being performed), multiple drugs may be used in combination. It is imperative that practitioners using drugs for sedation/analgesia in children be aware of the adverse effect profile(s) of these drugs, both individually and in combination. The purpose of this review is to describe the adverse effects of sedative and reversal agents currently used in paediatric sedation/analgesia.
随着侵入性较小的非手术诊断和治疗技术应用于儿科人群，镇静/镇痛在儿科患者中的应用正在迅速扩展。被要求提供镇静的医疗服务提供者可能包括放射科医生、儿科医生、护士和急诊科医生，以及麻醉科医生和重症监护医生。与此同时，这些情况下使用的药物范围也有了相当大的扩展。由于没有单一药物符合理想镇静剂的标准（起效快、恢复快、无不良反应、与所进行的操作相适应的制动效果），可能会联合使用多种药物。使用药物进行儿童镇静/镇痛的从业者必须了解这些药物单独使用和联合使用时的不良反应情况。本综述的目的是描述目前用于儿科镇静/镇痛的镇静剂和逆转剂的不良反应。
