Mondaini N, Ponchietti R, Muir G H, Montorsi F, Di Loro F, Lombardi G, Rizzo M
Department of Urology, University of Florence, Italy.
Int J Impot Res. 2003 Jun;15(3):225-8. doi: 10.1038/sj.ijir.3901005.
Sildenafil is one of two oral drugs approved for first-line treatment of erectile dysfunction (ED). Anecdotally, some young healthy men who wish to enhance their sexual performance are requesting or abusing sildenafil. In this randomized double-blind, placebo-controlled clinical study, we investigated the effect of sildenafil in young men without ED. A total of 60 young healthy men age 20-40 y with no reported ED were enrolled for this single-dose home-use study. Subjects had used no medication in the 6 months prior to the study. All had been engaged in a stable relationship for at least 3 months. After completing the IIEF-5 questionnaire, patients were randomized in a double-blind fashion to receive either one 25 mg tablet of sildenafil (group 1) taken prior to intercourse, or an identical placebo tablet (group 2). All subjects completed a questionnaire relating to their erectile quality. There were no differences between the two groups in the reported improvement of erection quality, 12/30 sildenafil vs 10/30 placebo (Fisher's test, P=0.79). Sildenafil caused a significant reduction of the postejaculatory refractory time (12/30 vs 4/30) (chi(2) test, P=0.04). Sildenafil does not improve erections in young healthy men. Sildenafil should not be given to young healthy men to improve their erections and patients should be advised against recreational abuse of the drug. In this limited single-dose home study, sildenafil appears to reduce the postorgasmic refractory time. Although controlled studies are needed to evaluate the efficacy of erection-enhancing drugs in premature ejaculation, it is possible that sildenafil might be useful for this indication.
西地那非是被批准用于一线治疗勃起功能障碍（ED）的两种口服药物之一。据传闻，一些希望增强性功能的年轻健康男性正在索要或滥用西地那非。在这项随机双盲、安慰剂对照的临床研究中，我们调查了西地那非对无勃起功能障碍的年轻男性的影响。共有60名年龄在20 - 40岁、无勃起功能障碍报告的年轻健康男性参与了这项单剂量家庭使用研究。受试者在研究前6个月未使用任何药物。所有人都维持稳定关系至少3个月。完成国际勃起功能指数-5问卷后，患者以双盲方式随机分组，在性交前服用一片25毫克的西地那非（第1组）或一片相同的安慰剂（第2组）。所有受试者都完成了一份关于其勃起质量的问卷。在报告的勃起质量改善方面，两组之间没有差异，西地那非组30人中有12人，安慰剂组30人中有10人（费舍尔检验，P = 0.79）。西地那非导致射精后不应期显著缩短（30人中有12人 vs 30人中有4人）（卡方检验，P = 0.04）。西地那非并不能改善年轻健康男性的勃起功能。不应给年轻健康男性服用西地那非来改善勃起功能，并且应该建议患者不要 recreational abuse of the drug（此处原文可能有误，推测是recreational use of the drug，即不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of the drug指不要 recreational use of 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