Warsi Asra, LaValley Michael P, Wang Philip S, Avorn Jerry, Solomon Daniel H
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 341, Boston, MA 02115, USA.
Arthritis Rheum. 2003 Aug;48(8):2207-13. doi: 10.1002/art.11210.
Some reports suggest that education programs help arthritis patients better manage their symptoms and improve function. This review of the published literature was undertaken to assess the effect of such programs on pain and disability.
Medline and HealthSTAR were searched for the period 1964-1998. The references of each article were then hand-searched for further publications. Studies were included in the meta-analysis if the intervention contained a self-management education component, a concurrent control group was included, and pain and/or disability were assessed as end points. Two authors reviewed each study. The methodologic attributes and efficacy of the interventions were assessed using a standardized abstraction tool, and the magnitude of the results was converted to a common measure, the effect size. Summary effect sizes were calculated separately for pain and disability.
The search strategy yielded 35 studies, of which 17 met inclusion criteria. The mean age of study participants was 61 years, and 69% were female. On average, 19% of patients did not complete followup (range 0-53%). The summary effect size was 0.12 for pain (95% confidence interval [95% CI] 0.00, 0.24) and 0.07 for disability (95% CI 0.00, 0.15). Funnel plots indicated no significant evidence of bias toward the publication of studies with findings that showed reductions in pain or disability.
The summary effect sizes suggest that arthritis self-management education programs result in small reductions in pain and disability.
一些报告表明,教育项目有助于关节炎患者更好地管理症状并改善功能。本对已发表文献的综述旨在评估此类项目对疼痛和残疾的影响。
检索了1964年至1998年期间的Medline和HealthSTAR数据库。然后人工检索每篇文章的参考文献以查找更多出版物。如果干预措施包含自我管理教育成分、设有同期对照组且将疼痛和/或残疾作为终点进行评估,则将这些研究纳入荟萃分析。两位作者对每项研究进行了审查。使用标准化的摘要工具评估干预措施的方法学属性和疗效,并将结果的大小转换为一种通用度量,即效应量。分别计算疼痛和残疾的汇总效应量。
检索策略共获得35项研究,其中17项符合纳入标准。研究参与者的平均年龄为61岁,69%为女性。平均而言,19%的患者未完成随访(范围为0 - 53%)。疼痛的汇总效应量为0.12(95%置信区间[95%CI]为0.00,0.24),残疾的汇总效应量为0.07(95%CI为0.00,0.15)。漏斗图表明,没有显著证据表明存在偏向发表疼痛或残疾减轻研究结果的偏倚。
汇总效应量表明,关节炎自我管理教育项目可使疼痛和残疾略有减轻。