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[对水泥工人手部使用防护药膏(Ivosin)的双盲试验]

[Double blind test with a protective ointment (Ivosin) on the hands of cement workers].

作者信息

Amphoux M, Robin J

出版信息

Berufsdermatosen. 1975 Dec;23(6):214-26.

PMID:129056
Abstract

56 builder's labourers manipulating lime cement applied a protective cream on their hands and 57 used a placebo in a double blind test of two months' duration. The labourers, the doctors who surveyed the condition of their hands, and the statistician who analyzed the results knew only that one cream had a blue label, and the other a green one. Before and after the test, the presence or the absence of certain symptoms on the hands were objectively examined, while the subjective opinion of the labourers was registered at the end of the test. As usual in tests of that kind, the great majority of the labourers (more than 75%) were satisfied, 62% of them acknowledged an improvement. That percentage justified a comparative double-blind study that revealed a much higher quota (86% of the test persons) of satisfaction among the labourers treated with Ivosin than in the placebo group (66%). That difference was statistically significant. On the other hand, no objective difference could be revealed between the two groups. It was impossible to discover among the symptoms studied, any objective cause of that subjective difference.

摘要

56名建筑工人在涂抹石灰水泥时会在手上涂抹防护霜,57人在为期两个月的双盲试验中使用了安慰剂。这些工人、检查他们手部状况的医生以及分析结果的统计学家只知道一种面霜有蓝色标签,另一种有绿色标签。在测试前后,对手部某些症状的有无进行了客观检查,而工人的主观意见在测试结束时进行了记录。和那种测试中常见的情况一样,绝大多数工人(超过75%)感到满意,其中62%的人承认有改善。这个百分比证明了一项对比双盲研究的合理性,该研究表明,使用伊沃辛治疗的工人中满意度更高(86%的测试对象),高于安慰剂组(66%)。这种差异具有统计学意义。另一方面,两组之间没有发现客观差异。在所研究的症状中,不可能发现这种主观差异的任何客观原因。

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