Sun Qiang, Zhou Yi-dong, Huang Han-yuan
Department of General Surgery, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Feb;25(1):93-5.
To study the clinical features and histologic criteria of Paget's disease of breast, and evaluate the potential prognostic factors for better appropriate treatment strategies.
Thirty-three patients treated for Paget's disease of breast were reviewed retrospectively.
The median age of diagnosis was 57 years. Twenty-nine patients were treated by modified radical mastectomy, 4 cases by mastectomy. Twenty-three (69.7%) patients had underlying carcinoma. Twenty-six (78.8%) patients did not have a palpable breast mass, 10 of them was simple Paget's disease, eight had ductal carcinoma in situ, eight had invasive ductal carcinoma. Seven patients had a palpable breast mass, and none of them was simple Paget's disease, except one of them had ductal carcinoma in situ, six had invasive ductal carcinoma.
Most patients with Paget's disease had associated breast carcinoma. Paget's disease of the breast with a palpable breast mass is more likely to be accompanied by an invasive ductal carcinoma and had a poor prognosis. Patients with any nipple complaints deserve a serious investigation.
研究乳腺佩吉特病的临床特征和组织学标准，并评估潜在的预后因素，以制定更合适的治疗策略。
回顾性分析33例接受乳腺佩吉特病治疗的患者。
诊断时的中位年龄为57岁。29例行改良根治性乳房切除术，4例行乳房切除术。23例（69.7%）患者伴有潜在癌。26例（78.8%）患者乳房未触及肿块，其中10例为单纯佩吉特病，8例为导管原位癌，8例为浸润性导管癌。7例患者乳房可触及肿块，除1例为导管原位癌外，其余均不是单纯佩吉特病，6例为浸润性导管癌。
大多数佩吉特病患者伴有乳腺癌。乳房可触及肿块的乳腺佩吉特病更可能伴有浸润性导管癌，预后较差。任何有乳头症状的患者都应进行认真检查。
