Cheng Zhi-qiang, Yin Wei, Fan Ji-yuan, Ma Tong-jun
Department of Endocrinology, General Hospital, Tianjin Medical University, Tianjin 300075, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Jun;24(3):306-9.
To investigate the effectiveness of alendronate Chinese national product in the prevention and treatment of postmenopausal osteoporosis.
The 56 postmenopausal women with osteopenia or osteoporosis were randomly divided into two groups: treated with alendronate 10 mg/d (28 cases) orally and placebo (28 cases), for 6 months. All subjects received 600 mg/d of calcium carbonate and vitamin D 1,000 U/d. Bone mineral density (BMD) of the lumbar spine, femoral neck, trochanter and Ward's triangle were measured by dual energy X-ray absorptiometry as well as the markers of bone turnover were analysed at the beginning and the end of the study.
The results showed that lumbar spine BMD increased by 5% in the alendronate group (P < 0.01), but decreased in BMD of the lumbar spine and femur in the placebo group (P < 0.05) after 6 months of treatment. In the alendronate group the marker of bone resorption and bone formation were significantly decreased after alendronate therapy. There were no change in placebo group.
Alendronate (Chinese national product) is effective in reducing bone turnover and promoting bone mass of postmenopausal osteoporosis.
探讨国产阿仑膦酸钠在防治绝经后骨质疏松症中的有效性。
将56例患有骨质减少或骨质疏松症的绝经后女性随机分为两组：一组口服阿仑膦酸钠10mg/d（28例），另一组口服安慰剂（28例），疗程6个月。所有受试者均补充碳酸钙600mg/d及维生素D 1000U/d。研究开始及结束时采用双能X线吸收法测量腰椎、股骨颈、大转子及Ward三角区的骨密度，并分析骨转换标志物。
结果显示，治疗6个月后，阿仑膦酸钠组腰椎骨密度增加了5%（P<0.01），而安慰剂组腰椎和股骨骨密度下降（P<0.05）。阿仑膦酸钠治疗后，阿仑膦酸钠组骨吸收和骨形成标志物显著降低，安慰剂组无变化。
国产阿仑膦酸钠可有效降低绝经后骨质疏松症患者的骨转换并增加骨量。
