[颈内动脉闭塞性疾病急性缺血性卒中患者的动脉内溶栓治疗]
[Intra-arterial thrombolysis in patients with acute ischemic stroke of the cervical internal carotid artery occlusive disease].
作者信息
Zhang Qing, Jin Zheng-yu, Huang Yi-ning, Xu Wei-hai, Ren Zu-yuan, Su Chang-bao, Wang Ren-zhi, Liu Wei, Pan Jie, Cui Li-ying, Gao Shan, Ye Jian, Dai Jian-ping
机构信息
Department of Radiology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Dec;24(6):646-9.
OBJECTIVE
To observe the safety and efficacy of local intra-arterial thrombolysis (LIT) in patients with acute ischemic stroke of cervical internal carotid artery occlusive disease.
METHODS
10 patients were treated by LIT. 2 of 10 patients were further treated by either angioplasty or endarterectomy. Primary neuroradiological assessment was performed with CT in all patients. Angiographic recanalization level was classified according to thrombolysis in myocardial infarction (TIMI) grades. Clinical outcome was classified as good for Modified Rankin Scale (MRS) scores of 0 to 3 and as poor for MRS scores of 4 to 6.
RESULTS
Complete/partial recanalization after infusion was accomplished in 8 patients, seven of whom had good clinical outcome. Cerebral hemorrhage occurred in 2 of 10 patients.
CONCLUSION
The results of this study suggest that LIT may be helpful to improve the outcome in patients with acute cervical internal carotid artery occlusive disease if it is performed within 6 hours of stroke onset.
目的
观察局部动脉内溶栓（LIT）治疗颈内动脉闭塞性疾病所致急性缺血性卒中患者的安全性和有效性。
方法
10例患者接受了局部动脉内溶栓治疗。10例患者中有2例进一步接受了血管成形术或动脉内膜切除术。所有患者均行CT进行初次神经放射学评估。血管造影再通水平根据心肌梗死溶栓（TIMI）分级进行分类。临床结局根据改良Rankin量表（MRS）评分分为良好（0至3分）和不良（4至6分）。
结果
8例患者在输注后实现了完全/部分再通，其中7例临床结局良好。10例患者中有2例发生脑出血。
结论
本研究结果表明，如果在卒中发作6小时内进行局部动脉内溶栓，可能有助于改善颈内动脉闭塞性疾病急性发作患者的结局。
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