Lu Zhao-hui, Chen Jie
Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Apr;25(2):233-6.
TGF-beta signal pathway plays an important role in the cell growth, differentiation, formation of extracellular matrix, embryo development and carcinogenesis, etc. However, the regulation of TGF-beta pathway is not totally understood. In 1999, three independent research groups found that Ski/SnoN protein could inhibit the TGF-beta mediated transcription by recruiting N-CoR, a transcription co-repressor. Later studies suggested that TGF-beta and SMADs degraded the Ski/SnoN protein by mediating ubiquitin linkage, showing negative feedback regulation. The important findings in Ski/SnoN laid the theoretical foundation for demonstrating the function of TGF-beta signal pathway.
转化生长因子-β（TGF-β）信号通路在细胞生长、分化、细胞外基质形成、胚胎发育和肿瘤发生等过程中发挥着重要作用。然而，TGF-β信号通路的调控机制尚未完全明确。1999年，三个独立的研究小组发现，Ski/SnoN蛋白可通过募集转录共抑制因子N-CoR来抑制TGF-β介导的转录。随后的研究表明，TGF-β和SMAD蛋白通过介导泛素连接来降解Ski/SnoN蛋白，呈现出负反馈调节。Ski/SnoN方面的这些重要发现为阐明TGF-β信号通路的功能奠定了理论基础。
