Lisak R P, Bealmear B
Department of Neurology, Wayne State University, School of Medicine, Detroit, Mich. 48201.
Pathobiology. 1992;60(6):322-9. doi: 10.1159/000163743.
We compared the capacity of unfractionated cytokines and recombinant gamma-interferons (gamma-IFN) to induce major histocompatibility (MHC) antigens on neonatal rat Schwann cells and endoneurial fibroblasts in vitro. Rat and mouse gamma-IFN were capable of induction of both class I and class II MHC antigens on both cell types although rat gamma-IFN was more potent than that of mouse. Human gamma-IFN failed to induce MHC class I or class II on either cell type. Unfractionated cytokines from the different species also differed in their capacity to induce MHC antigens. Differences in species of origin of cytokine mixtures as well as in individual cytokines, such as gamma-IFN need to be considered in studies of MHC induction. The presence of MHC class I and class II antigens on Schwann cells could render them susceptible to cytotoxic reactions and allow for the presentation of antigen, respectively.
我们比较了未分级的细胞因子和重组γ干扰素（γ-IFN）在体外诱导新生大鼠雪旺细胞和神经内膜成纤维细胞上主要组织相容性（MHC）抗原的能力。大鼠和小鼠γ-IFN能够在两种细胞类型上诱导I类和II类MHC抗原，尽管大鼠γ-IFN比小鼠γ-IFN更有效。人γ-IFN未能在任何一种细胞类型上诱导MHC I类或II类抗原。来自不同物种的未分级细胞因子在诱导MHC抗原的能力上也存在差异。在MHC诱导研究中，需要考虑细胞因子混合物的来源物种以及个别细胞因子（如γ-IFN）的差异。雪旺细胞上存在MHC I类和II类抗原可能分别使它们易受细胞毒性反应影响并允许抗原呈递。
