De Lucca R C, Mandalunis P M, Ubios A M
Department of Histology and Embryology, Faculty of Dentistry, University of Buenos Aires.
Acta Odontol Latinoam. 1999;12(2):75-81.
The present study reveals the inhibitory effect of iron intoxication on the process of dentine mineralization. Wistar rats were injected intraperitoneally with iron dextran at 0.88 g/kg body weight per day for 10 days during the period of odontogenesis. An age-matched group was injected intraperitoneally with bisodium etidronate (EHBP) at 20 mg/kg body weight per day for 10 days. Another age-matched group was treated with similar amounts of saline intraperitoneally and considered as control. At the end of the experimental period the animals intoxicated with iron exhibited non-mineralized dentine and mineralized bone. The animals treated with EHBP showed non-mineralized dentine and bone. These findings would suggest the existence of different mineralization mechanisms for bone and dentine.
本研究揭示了铁中毒对牙本质矿化过程的抑制作用。在牙胚发生期，给Wistar大鼠每天腹腔注射右旋糖酐铁，剂量为0.88 g/kg体重，持续10天。将年龄匹配的一组大鼠每天腹腔注射依替膦酸二钠（EHBP），剂量为20 mg/kg体重，持续10天。另一组年龄匹配的大鼠腹腔注射等量的生理盐水作为对照。在实验期结束时，铁中毒的动物表现出未矿化的牙本质和矿化的骨骼。用EHBP治疗的动物表现出未矿化的牙本质和骨骼。这些发现表明骨和牙本质存在不同的矿化机制。
