Maldonado J, Pego M, Bastos M, Guimarães H, Monteiro V, Providência L A
Serviço de Cardiologia, Hospitais da Universidade de Coimbra.
Rev Port Cardiol. 1992 Nov;11(11):929-32.
To determine the arterial compliance through the evaluation of pulse wave velocity.
Open study with direct comparison of different groups within a 12 week evaluation period.
69 patients, 49 with hypertension and 20 normals individuals.
Different groups with the following treatments: Isradipine, Lisinopril, Dilevalol and no therapy.
There is marked differences in the pulse wave velocity when hypertensive patients are compared with normal individuals (p < 0.001). In a 12 week therapeutic evaluation there is an improvement in the pulse wave velocity particularly when the arterial pressure was lowered to normal values in the hypertensive patients: Lisinopril (p < 0.005), Isradipine (p < 0.005), Dilevalol (p < 0.025).
It is very easy to evaluate the pulse wave velocity. Arterial compliance, which may be evaluated using the pulse wave velocity, is significantly reduced in hypertensive patients, compared with age-matched control subjects. The use of antihypertensive drugs is associated with changes in arterial compliance. There is a significant decrease in the pulse wave velocity after the administration of ACE inhibitors, calcium channel blockers and beta blockers for an equivalent fall in blood pressure. These observations emphasizes the potential importance of the changes in the large arteries, considered as either an associated factor or a consequence of elevated blood pressure, in the evaluation of the cardiovascular morbidity, and mortality of patients treated for hypertension.
通过评估脉搏波速度来确定动脉顺应性。
在12周的评估期内进行开放研究，对不同组进行直接比较。
69名患者，49名高血压患者和20名正常个体。
不同组采用以下治疗方法：伊拉地平、赖诺普利、地来洛尔和不进行治疗。
高血压患者与正常个体相比，脉搏波速度存在显著差异（p < 0.001）。在12周的治疗评估中，脉搏波速度有所改善，尤其是当高血压患者的动脉压降至正常水平时：赖诺普利（p < 0.005）、伊拉地平（p < 0.005）、地来洛尔（p < 0.025）。
评估脉搏波速度非常容易。与年龄匹配的对照受试者相比，高血压患者中可通过脉搏波速度评估的动脉顺应性显著降低。使用抗高血压药物与动脉顺应性的变化有关。在给予血管紧张素转换酶抑制剂、钙通道阻滞剂和β受体阻滞剂后，脉搏波速度显著降低，血压下降幅度相当。这些观察结果强调了大动脉变化在评估高血压治疗患者心血管发病率和死亡率中的潜在重要性，大动脉变化被视为高血压升高的相关因素或后果。
